I'm trying to create an alert on disk drive space (ie. E: drive if it get say 80% full) send an alert via email to me.
Just customize the out of the box disk space alert and add a filter for Manufacturer = VMware (or whomever makes your hypervisor).
Thanks KMSigma, sorry but I'm new in SW. Is there a link or procedure on how to get to the out of the box alerts and add filters?
Yep - Create new alerts to monitor your environment with the Orion Platform (solarwinds.com)
In your instance, just find the one that's close (probably a disk space warning one) check the box and select Duplicate and Edit.