If an Orion server has two NICs, each cabled to two different networks which can not see each other, will Orion be able to poll both networks?
I think the key is, if the server see both networks. Orion doesn't control the routing, it depends on the OS for that. if you can open a cmd prompt and ping the seperate networks, then Orion should have no problems.
(maybe I should have refreshed the page before I posted)
Yes. That ability is mostly an OS feature. Just make sure you can ping each network from the OS and you'll be good.