I was recently doing research about Packet Loss/Packet Discards for myself and came across the fact that HUGE BUFFER MISSES is probably the most important of those buffers to indicate a serious problem. One suggestion I came across was using this command in the IOS configuration. You might check it for further review to see if it helps your case.
http://www.cisco.com/en/US/docs/ios/netmgmt/command/reference/nm_02.html#wp1181763
I would first go to the switch and make sure it is seeing it the same way SW is.
If they agree on the misses then it would be best to do something. The whole thing can snowball because when a pool is exhausted the next pool in line gets used.
Also keep in mind that cranking up your buffers eats memory. On a newer switch especially chassis switches thats not a big deal but that closet switch you have there it might indeed be a big deal since they tend to use a lot of their memory normally anyway.
Also I believe that "buffers tune automatic" is for routers only. If you look at the doc you will notice everything mentioned are router trains.