Is it possible in Orion 8.5.1 or 9 to alert if a device (Cisco particularly) configuration changes? If so how?
You could use syslog to accomplish this. Whenever a configuration change takes place it can log that to syslog and you can configure Orion to pick up on key words in Syslog messages to trigger an alert.
That is correct. Realtime Change Detection was actually available in v4 (see http://www.solarwinds.com/products/cirrus/network_config_change_management.aspx). With v5, you'll be able to leverage the built-in syslog and snmp trap server.