Is there a way to set up an alert and/or Template to notify when Exchange performance is being affected by low disk space or I/O? if so how would I go about doing that? or would the best bet be to open a support case?
AppInsight for Exchange Monitors this information for you already out-of-the-box.
There are even pre-built out-of-the-box alerts configured for you in the Advanced Alert Manager for space/size issues related to Exchange
Thanks again for the prompt answers. They are greatly appreciated.