For Adobe Products, I have the option to use EXE or MSI. Which one is best to use and why?
The primary advantage to using the MSI-based installer is that it can be remotely uninstalled via the Windows Installer Service.
EXE's are a bit harder to uninstall, and quite often cannot be done so remotely.
From the perspective of Patch Manager, the product provides a tool in Computer Explorer -> Installed Software to do remote uninstallation of MSI-based products.