Excessive packet fragmentation can cause a performance hit on CPU based routers. It would be nice if NPM had an integrated monitor for this. Its very doable with a custom poller but something integrated would be much cleaner.
Some of the OIDs you can poll are:
1.3.6.1.2.1.4.17 ipFragOKs
1.3.6.1.2.1.4.15 ipReasmOKs