Stealing Rob's answer from Solarwinds server timezone change from AEST to UTC:
You may lose a few hours of historical data and have some bogus alerts for a few minutes when it comes back up, but going forward there should be no issues. It would be advised to stop Orion services before making the change.
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agreed with cobrien - when you change the boxes you may see IMMEDIATE issues, but nothing long term. If you have multiple pollers, make sure they ALL are set to the same time zone (otherwise you will have data that doesn't match up. Also make sure your database server is set to the same time zone as the primary poller. Having those two guys in different time settings (even if they physically sit next to each other) is a documented no-no.