We are seeing this same issue in our environment. Anybody have a solution?
I've read your comment couple of times and I'm wondering the following. is the "Specific site" a remote site? is it LAN or VPN connected network? do you use any Proxy along the way?
on our old forum there is a thread : dameware.com • View topic - Error: "Failed to establishing a security context" (-2146893
can you try what this thread mentions?