By what du you mean support ?:-)
From what I can read/know TR-069 is HTTP SOAP appl. that communicate from your OSS/BSS to the WIMAX/LTE CPE right?
1.Solarwinds NPM can monitor with help of SNMP/ICMP/WMI that server that run TR-069 service.
2.NPM can monitor the VLAN/VRF/IP that service use to communicate.
3.SAM (Application Performance Monitor) should could monitor that SOAP interface (service)but I'm not sure.
TR-069 is a management framework, just like SNMP. This is typically used by ISPs to support end-devices and is used to support things like 'zeroconfig' where you buy a DSL modem/router from your nearest store, plug it in, the modem locates the ACS, negotiates with it to obtain firmware updates and the correct network configuration, present the user with a captive portal, etc. It can also do proxy management of home networking devices.
[I used to work for Motive, now part of Alcatel-Lucent, that sells software for managing this experience]
Anyway, layered on top of TR-069 are the device models (think SNMPmibs) that describe how you would manage the CPE ddevice, and proxy-manage any home networking devices. Typically (I've never seen it done any other way) OSS/BSS interact with the ACS rather than the CPE devices. As an interesting problem the Wireless-Controller (~= ACS) and thin AP (~=CPE device) is probably the closest model NPM has, in which case integrating with your ACS might be what you're asking for.
TR-069 alone doesn't give much functionality, it's what you want to gather with it that makes it useful, and that's not articulated in the question.
NPM doesn't support TR-069; I think you'd need to talk with the product manager about what you really need.
RL: you are correct in that TR-069 is basically SNMP on steroids and is used as the standard remote monitoring and management protocol type for WiMAX/LTE-based networks.
However, these WiMAX/LTE devices do not support SNMP by the nature of their respective technology profiles - so my ultimate question would be is if my NPM would still be able to monitor these devices in terms of telling me their status (up/down/failing) and the statistics of their connection (throughput/RSSI/modulation/etc.) - you know, all the things that are normally monitored through SNMP?