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Sure I have a pointer for you. There is an MS hotfix that blocks Orion -> vCenter communications that should be removed on pollers and the vCenter:
We have the virtualization piece of NPM implemented but I never use it (I prefer vCenter.) I've demo'd Virtualization Manager along with Storage Manager, and I liked its reporting and SAN integration much better.
Haven't seen much value in NPM's virtualization piece that I can't get at-a-glance in vCenter.