You can create a customized dashboard using search queries for example to only show cluster 1, where you will need to use a search query for each widget on the dashboard.
It is a similar process outlined here Creating a Virtual Desktop (VDI) Perspective With Virtualization Manager
Each user can make a dashboard private to them so another user won't see it when they log in.
However, each user will still have the ability to query the whole environment.
Many thanks Jonathan, it was exactly I was trying to do...
Of course, it's not a real user profile/limitation but it is better than nothing! ;)