If you goto Add Remove Programs
UnInstall Orion Core Services 2010.1
UnInstall Orion Network Performance Monitor v10.0
If you have any NPM Modules Uninstall these too.
Afterwards ReInstall the Products Orion NPM
and if possible leave it itstall to default Location
And this should resolves your Issues.
If not please log a Support ticket and we will help resolve this ASAP.
Thank you Kevin. Suggestion worked. I had tried reinstalling a few times, but in different partitions than the default provided.
Once you tried Kevin's suggestion, would you post your results for the benefit of the community?