I know that if one changes the ICMP or SNMP interval settings and then clicks on the "Re-Apply" button that it will apply to all objects in the database.
Is it necessary to also click on the Submit button at the bottom of the page?
The submit button just confirms that you've chosen to change the previous polling intervals for new nodes being added going forward. The 're-apply' button goes back and updates all the existing nodes. So, if you don't mean to update all your existing nodes, just hit Submit and call it good.