That is a very odd situation. I would contact support since there is nothing in hotfix 4 that would have done this situation. It sounds like you have a rule that may be firing on a start event that is doing an active response of closing a program out.
You are correct. I found a rule that would fire. It was closing any suspicious programs that would use two file extensions to run. I just deleted it for now so everyone can use Adobe again. Thanks for replying!
Disable the "Kill Suspicious Process" rule. That did it for us.