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To pass null from Python, don't send 'null' (which is a 4-character string containing n, u, l, and l). Instead send None (with no quotes). This will get translated to JSON as null (again, no quotes) and should do what you want.
Thank you, that works great. This is what I ended up with.
t = [ "NO", "ITTSUNIX", "ITTSWINDOWS", "ITTSNETWORK" ]
swis = SwisClient(config.npm_server, config.username, config.password)
results = swis.invoke(
'Excludes IT resources from Netcool alarms if set to NO',