I had a case the other day here where we were not able to get the login to connect on to the repository on an AG group from one node and could from the other. In that case the login was a windows authentication account and from one node it was working to login and from the other it would not without adding a JDBC property for useNTLMv2=true to the repo.properties file.
I would say to try adding this property to the file listed <DPA Home>/iwc/tomcat/ignite_config/idc/repo.properties
Here is a good link on understanding this item.
I am not sure but, perhaps the from the one replica you are needing NTLM auth and we are not trying that with out this setting. If this doesn't work please turn in a support case and reference this discussion and if we find the solution we can update this item.
jaminsql Thanks for the suggestion. I will try this out; however, the login we're using to connect to the repository is a sql login and not windows authentication. Have you or anyone else experienced something similar with a sql login before?