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Latency and setting up of alerts/polling

Hi All.

We have a new setup( will be in HA mode) coming up where in the latency would be around 300ms and its spread across multiple DCs.  We would be having servers, network devices, hypervisors for monitoring in this setup.Wanted to know from ppl here have similar setups and if they found any issues.

Also need some input on below points:

1. Should the default polling intervals be left alone?

2. If i do change the polling interval to 5 min then when i configure the alerts, should the evaluate trigger and other condition be kept at more than 5 min?