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Access List Changes with Variables

I have over 1000 routers that I need to update the access lists on.  The access lists are basically the same except the source address and source wildcard bits are different

For example Router A it might be

access-list 101 permit ip 172.16.200.0 0.0.0.15 172.20.0.0 0.3.255.255

and Router B might be

access-list 101 permit ip 172.16.200.16 0.0.0.15 172.20.0.0 0.3.255.255

What is the best way to handle this?  Is there a way to write a script that will pull the source address and source wildcard bits from an excel document and insert the appropriate address and update the configuration on the router?