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Auto-reply for Closed Incidents

Our tenant has the Global Service Desk Setting "Reopen Resolved/Closed Incidents" toggle, set to Off, to preventer Requester or anyone CC'd from re-opening the Incident by Commenting. 

Is it possible to display an alert or send an email auto-reply to anyone who comments on a Closed Incident reminding them "This Incident is Closed, please create a new Incident" or similar?

Thanks